Principal Investigators

Dr. Caroline Bergner

Dr. Caroline Bergner

Aberrant microglia function as drivers of neuroaxonal degeneration in diseases of the white matter

Caroline Bergner, Stefan Nessler, Christine Stadelmann-Nessler

Universitätsklinikum Leipzig
Universitätsmedizin Göttingen

Microglia instruct the toxic microenvironment in transplantable leukodystrophies

Caroline Bergner, Stefan Nessler, Christine Stadelmann-Nessler

Universitätsklinikum Leipzig
Universitätsmedizin Göttingen
Dr. Stefan Nessler

Dr. Stefan Nessler

Aberrant microglia function as drivers of neuroaxonal degeneration in diseases of the white matter

Caroline Bergner, Stefan Nessler, Christine Stadelmann-Nessler

Universitätsklinikum Leipzig
Universitätsmedizin Göttingen

Microglia instruct the toxic microenvironment in transplantable leukodystrophies

Caroline Bergner, Stefan Nessler, Christine Stadelmann-Nessler

Universitätsklinikum Leipzig
Universitätsmedizin Göttingen
Prof. Dr. Christine Stadelmann-Nessler

Prof. Dr. Christine Stadelmann-Nessler

Aberrant microglia function as drivers of neuroaxonal degeneration in diseases of the white matter

Caroline Bergner, Stefan Nessler, Christine Stadelmann-Nessler

Universitätsklinikum Leipzig
Universitätsmedizin Göttingen

Microglia instruct the toxic microenvironment in transplantable leukodystrophies

Caroline Bergner, Stefan Nessler, Christine Stadelmann-Nessler

Universitätsklinikum Leipzig
Universitätsmedizin Göttingen
PD Dr. Chotima Böttcher

PD Dr. Chotima Böttcher

The continuum of microglial subpopulations to functional changes in multiple sclerosis

Chotima Böttcher, Zoltan Takats

Charité Berlin
Imperial College London
Prof. Dr. Zoltan Takats

Prof. Dr. Zoltan Takats

The continuum of microglial subpopulations to functional changes in multiple sclerosis

Chotima Böttcher, Zoltan Takats

Charité Berlin
Imperial College London
Prof. Dr. Frank Bradke

Prof. Dr. Frank Bradke

The cytoskeleton as a signaling node that contributes to microglia activation and diversity

Frank Bradke, Annett Halle

DZNE Bonn

Actin cytoskeleton disturbance as a driver of cellular dysfunction and cell state diversity in microglia

Frank Bradke, Annett Halle

DZNE Bonn
Dr. Annett Halle

Dr. Annett Halle

The cytoskeleton as a signaling node that contributes to microglia activation and diversity

Frank Bradke, Annett Halle

DZNE Bonn

Actin cytoskeleton disturbance as a driver of cellular dysfunction and cell state diversity in microglia

Frank Bradke, Annett Halle

DZNE Bonn
Dr. Sophie Crux-Daseking

Dr. Sophie Crux-Daseking

The role of microglial cytoskeleton proteins ADF/Cfl1 in learning and memory

Sophie Crux-Daseking, Martin Fuhrmann

DZNE Bonn

The role of microtubule cytoskeleton modulation in microglia and its effect on cognition

Sophie Crux-Daseking, Martin Fuhrmann

DZNE Bonn
Prof. Dr. Martin Fuhrmann

Prof. Dr. Martin Fuhrmann

The role of microglial cytoskeleton proteins ADF/Cfl1 in learning and memory

Sophie Crux-Daseking, Martin Fuhrmann

DZNE Bonn

The role of microtubule cytoskeleton modulation in microglia and its effect on cognition

Sophie Crux-Daseking, Martin Fuhrmann

DZNE Bonn

Spatio-temporal profiling of microglial heterogeneity and dynamics in glioblastoma

Felix Nebeling, Martin Fuhrmann

DZNE Bonn
PD Dr. Charlotte Flüh

PD Dr. Charlotte Flüh

Multidimensional analysis and therapeutic targeting of microglia fostering brain tumor relapse

Charlotte Flüh, Rainer Glass

Universitätsklinikum Schleswig Holstein
LMU Klinikum München
Prof. Dr. Rainer Glass

Prof. Dr. Rainer Glass

Multidimensional analysis and therapeutic targeting of microglia fostering brain tumor relapse

Charlotte Flüh, Rainer Glass

Universitätsklinikum Schleswig Holstein
LMU Klinikum München
Prof. Dr. Christoph Kaleta

Prof. Dr. Christoph Kaleta

A humanized mouse model to analyse the age-dependent impact of gut microbiota on microglial diversity in the brain

Christoph Kaleta, Christiane Frahm, Christian Schmeer

Universitätsklinikum Jena
Christian-Albrechts-Universität zu Kiel
Dr. Christiane Frahm

Dr. Christiane Frahm

A humanized mouse model to analyse the age-dependent impact of gut microbiota on microglial diversity in the brain

Christoph Kaleta, Christiane Frahm, Christian Schmeer

Universitätsklinikum Jena
Christian-Albrechts-Universität zu Kiel
Dr. Christian Schmeer

Dr. Christian Schmeer

A humanized mouse model to analyse the age-dependent impact of gut microbiota on microglial diversity in the brain

Christoph Kaleta, Christiane Frahm, Christian Schmeer

Universitätsklinikum Jena
Christian-Albrechts-Universität zu Kiel
Prof. Dr. med. Karen Gertz

Prof. Dr. med. Karen Gertz

Myeloid Cell Diversity and Ischemic Stroke

Karen Gertz

Charité Berlin
Dr. Shirin Hosseini

Dr. Shirin Hosseini

Elucidating the role of activated microglia in sculpting neuronal circuits after respiratory viral infections

Shirin Hosseini, Martin Korte

TU Braunschweig
Helmholtz-Zentrum für Infektionsforschung
Prof. Dr. Martin Korte

Prof. Dr. Martin Korte

Elucidating the role of activated microglia in sculpting neuronal circuits after respiratory viral infections

Shirin Hosseini, Martin Korte

TU Braunschweig
Helmholtz-Zentrum für Infektionsforschung
Prof. Dr. Steffen Jung

Prof. Dr. Steffen Jung

Microglial IL-10 expression and the impact of CNS-wide microglia responses on higher brain function

Steffen Jung

Weizmann Institute of Science

Microglial IL-10 and Csf1r dependence - harnessing mouse models to decipher microglia biology

Steffen Jung

Weizmann Institute of Science
Prof. Dr. med. Harald Neumann

Prof. Dr. med. Harald Neumann

Desialyation as trigger of microglia responses in the aging and degenerating retina

Harald Neumann, Thomas Langmann

Universität zu Köln
Universitätsklinikum Bonn
Prof. Dr. Thomas Langmann

Prof. Dr. Thomas Langmann

Desialyation as trigger of microglia responses in the aging and degenerating retina

Harald Neumann, Thomas Langmann

Universität zu Köln
Universitätsklinikum Bonn
Dr. Sabina Tahirovic

Dr. Sabina Tahirovic

T cells as modulators of microglia-mediated neurodegeneration in Niemann Pick type C (NPC) disease

Sabina Tahirovic, Arthur Liesz

LMU Klinikum München
DZNE München

T cells as modulators of microglial reactivity in Alzheimer’s disease

Sabina Tahirovic, Arthur Liesz

LMU Klinikum München
DZNE München
Prof. Dr. Arthur Liesz

Prof. Dr. Arthur Liesz

T cells as modulators of microglia-mediated neurodegeneration in Niemann Pick type C (NPC) disease

Sabina Tahirovic, Arthur Liesz

LMU Klinikum München
DZNE München

T cells as modulators of microglial reactivity in Alzheimer’s disease

Sabina Tahirovic, Arthur Liesz

LMU Klinikum München
DZNE München
Prof. Dr. med. Tim Magnus

Prof. Dr. med. Tim Magnus

Microglia-neuron interaction during recovery after cerebral ischemia

Tim Magnus, Thomas Oertner

Universitätsklinikum Hamburg-Eppendorf
Center for Molecular Neurobiology Hamburg
Experimental Research in Stroke and Inflammation
Prof. Dr. med. Thomas Oertner

Prof. Dr. med. Thomas Oertner

Microglia-neuron interaction during recovery after cerebral ischemia

Tim Magnus, Thomas Oertner

Universitätsklinikum Hamburg-Eppendorf
Center for Molecular Neurobiology Hamburg
Experimental Research in Stroke and Inflammation
Prof. Dr. Alexander Mildner

Prof. Dr. Alexander Mildner

Influence of cytokines on microglial metabolism during Alzheimer’s disease

Alexander Mildner

University of Turku

Microglial lipid metabolism during physiological and pathological conditions

Alexander Mildner

University of Turku
Dr. Dr. Lukas Bunse

Dr. Dr. Lukas Bunse

Microglial immunosurveillance of oncogenic isocitrate dehydrogenase (CONVINCE-IDH)

Lukas Bunse, Michael Platten

Universitätsmedizin Mannheim
Medizinische Fakultät Heidelberg
Mannheim Center for Translational Neuroscience
Prof. Dr. Michael Platten

Prof. Dr. Michael Platten

Microglial immunosurveillance of oncogenic isocitrate dehydrogenase (CONVINCE-IDH)

Lukas Bunse, Michael Platten

Universitätsmedizin Mannheim
Medizinische Fakultät Heidelberg
Mannheim Center for Translational Neuroscience

Trained Spp1+ microglial immunity in glioma – (TRAINSPOTTING)

Michael Platten

Universitätsmedizin Mannheim
Medizinische Fakultät Heidelberg
Mannheim Center for Translational Neuroscience
Prof. Dr. Josef Priller

Prof. Dr. Josef Priller

A novel in vivo human-mouse chimeric brain model to study human microglia specification and contributions to neuropsychiatric disease

Josef Priller, Simon Schäfer

TU München

Elucidating sex-specific and disease-associated human microglia phenotypes and their contribution to Rett Syndrome

Josef Priller, Simon Schäfer

TU München
Prof. Dr. Simon Schäfer

Prof. Dr. Simon Schäfer

A novel in vivo human-mouse chimeric brain model to study human microglia specification and contributions to neuropsychiatric disease

Josef Priller, Simon Schäfer

TU München

Elucidating sex-specific and disease-associated human microglia phenotypes and their contribution to Rett Syndrome

Josef Priller, Simon Schäfer

TU München
Prof. Dr. Julio Saez-Rodriguez

Prof. Dr. Julio Saez-Rodriguez

MacTrac – Tracking spatio-temporal trajectories of macrophage subtypes in inflammatory demyelination

Julio Saez-Rodriguez, Lucas Schirmer, Simon Hametner

Universitätsmedizin Mannheim
Mannheim Institute for Innate Immunoscience
Mannheim Center for Translational Neuroscience
Medizinische Fakultät Heidelberg
Uniklinik Heidelberg
Medizinische Universität Wien
Prof. Dr. med. Lucas Schirmer

Prof. Dr. med. Lucas Schirmer

MacTrac – Tracking spatio-temporal trajectories of macrophage subtypes in inflammatory demyelination

Julio Saez-Rodriguez, Lucas Schirmer, Simon Hametner

Universitätsmedizin Mannheim
Mannheim Institute for Innate Immunoscience
Mannheim Center for Translational Neuroscience
Medizinische Fakultät Heidelberg
Uniklinik Heidelberg
Medizinische Universität Wien
Dr. Simon Hametner

Dr. Simon Hametner

MacTrac – Tracking spatio-temporal trajectories of macrophage subtypes in inflammatory demyelination

Julio Saez-Rodriguez, Lucas Schirmer, Simon Hametner

Universitätsmedizin Mannheim
Mannheim Institute for Innate Immunoscience
Mannheim Center for Translational Neuroscience
Medizinische Fakultät Heidelberg
Uniklinik Heidelberg
Medizinische Universität Wien
Dr. Leif S. Ludwig

Dr. Leif S. Ludwig

Genetic and non-genetic determinants of brain cancer-associated clonal myeloid cell dynamics and plasticity

Ilon Liu, Leif S. Ludwig

Charité Berlin
Max Delbrück Center Berlin
Berlin Institute of Health

Epigenomic states of microglia driving central nervous system repair in humans

Leif S. Ludwig

Charité Berlin
Max Delbrück Center Berlin
Berlin Institute of Health
Prof. Dr. Ari Waisman

Prof. Dr. Ari Waisman

The role of CYLD and A20 in microglia in aging and autoimmunity

Ari Waisman

Universitätsmedizin Mainz

The deubiquitinating enzyme A20 as gate keepers of central nervous system homeostasis

Ari Waisman

Universitätsmedizin Mainz
PD Dr. Corinne Benakis

PD Dr. Corinne Benakis

Chronic exposure to environmental pollutants and microglial molecular reprogramming in ischemic stroke

Corinne Benakis

LMU Klinikum München
Institute for Stroke and Dementia Research
Prof. Dr. Marco Prinz

Prof. Dr. Marco Prinz

Charting CNS-endogenous innate immune responses across cells and species

Marco Prinz

Universitätsklinikum Freiburg
Prof. Dr. Jovica Ninkovic

Prof. Dr. Jovica Ninkovic

The role of translation in shaping microglial activation states during neuroinflammation

Michael Kiebler, Jovica Ninkovic

LMU Klinikum München
Dr. Lars Päger

Dr. Lars Päger

Spatiotemporally resolved microglial diversity and reciprocal interaction with the noradrenergic system in Alzheimer’s disease

Lars Paeger, Felix Strübing

LMU Klinikum München
DZNE Bonn
Prof. Dr. Cornelia Deeg

Prof. Dr. Cornelia Deeg

Microglial dynamics in retinal diseases: Müller cells and T cells as local and peripheral interacting partners

Cornelia Deeg, Antje Grosche

LMU München
Prof. Dr. Antje Grosche

Prof. Dr. Antje Grosche

Microglial dynamics in retinal diseases: Müller cells and T cells as local and peripheral interacting partners

Cornelia Deeg, Antje Grosche

LMU München
Dr. Felix Nebeling

Dr. Felix Nebeling

Spatio-temporal profiling of microglial heterogeneity and dynamics in glioblastoma

Felix Nebeling, Martin Fuhrmann

DZNE Bonn
Prof. Dr. Michael Kiebler

Prof. Dr. Michael Kiebler

The role of translation in shaping microglial activation states during neuroinflammation

Michael Kiebler, Jovica Ninkovic

LMU Klinikum München
Prof. Dr. Dilja Krüger-Burg

Prof. Dr. Dilja Krüger-Burg

Microglial diversity in the remodeling of GABAergic synapses in corticolimbic circuits and anxiety-related behaviors

Dilja Krüger-Burg

Universitätsmedizin Mainz
Dr. Ilon Liu

Dr. Ilon Liu

Genetic and non-genetic determinants of brain cancer-associated clonal myeloid cell dynamics and plasticity

Ilon Liu, Leif S. Ludwig

Charité Berlin
Max Delbrück Center Berlin
Berlin Institute of Health
Dr. Felix Strübing

Dr. Felix Strübing

Spatiotemporally resolved microglial diversity and reciprocal interaction with the noradrenergic system in Alzheimer’s disease

Lars Paeger, Felix Strübing

LMU Klinikum München
DZNE Bonn
Prof. Dr. Mikael Simons

Prof. Dr. Mikael Simons

CD8+ tissue-resident T-cell regulation of microglia function

Mikael Simons, Doron Merkler

TU München
Université de Genève
Prof. Dr. Doron Merkler

Prof. Dr. Doron Merkler

CD8+ tissue-resident T-cell regulation of microglia function

Mikael Simons, Doron Merkler

TU München
Université de Genève