SPP 2395 – Lars Paeger

Deutsches Zentrum für Neurogenerative Erkrankungen

Neuron subtypes have distinct mitochondrial transport in axons and vulnerability to tau in vivo

Niedermeier, T., Feyen, P., Ochs, K., Misgeld, T., Herms, J., Paeger, L.

Natureportfolio under review (2025) doi: 10.21203/rs.3.rs-7628051/v1
Early Locus Coeruleus noradrenergic axon loss drives olfactory dysfunction in Alzheimer/’s disease

Meyer, C., Niedermeier, T., Feyen, P.L.C., Strübing, F.L., Rauchmann, B.-S., Karali, K., Gentz, J., Tillmann, Y.E., Landgraf, N.F., Rumpf, S.-L., Ochs, K., Wind-Mark, K., Biechele, G., Wagner, J., Guersel, S., Kurz, C.I., Schweiger, M., Prtvar, D., Shi, Y., Banati, R.B., Liu, G.-J., Middleton, R.J., Mitteregger-Kretzschmar, G., Perneczky, R., Koeglsperger, T., Neher, J.J., Tahirovic, S., Brendel, M., Herms, J., Paeger, L.

Nat Commun 16 (2025) doi: 10.1038/s41467-025-62500-8 pmid: 40781079

Myeloid cell-specific loss of NPC1 in mice recapitulates microgliosis and neurodegeneration in patients with Niemann-Pick type C disease.

Dinkel, L., Hummel, S., Zenatti, V., Malara, M., Tillmann, Y., Colombo, A., Monasor, L. S., Suh, J. H., Logan, T., Roth, S., Paeger, L., Hoffelner, P., Bludau, O., Schmidt, A., Muller, S. A., Schifferer, M., Nuscher, B., Njavro, J. R., Prestel, M., Bartos, L. M., Wind-Mark, K., Slemann, L., Hoermann, L., Kunte, S. T., Gnorich, J., Lindner, S., Simons, M., Herms, J., Paquet, D., Lichtenthaler, S. F., Bartenstein, P., Franzmeier, N., Liesz, A., Grosche, A., Bremova-Ertl, T., Catarino, C., Beblo, S., Bergner, C., Schneider, S. A., Strupp, M., Di Paolo, G., Brendel, M., Tahirovic, S.

Sci Transl Med 16, 776 (2024) doi: 10.1126/scitranslmed.adl4616 pmid: 39630885