SPP 2395 – Michael Platten

Prof. Dr. Michael Platten

Medical Faculty Mannheim of Heidelberg University
Mannheim Center for Translational Neurosience
Department of Neurology
German Cancer Research Center
Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology

michael.platten@medma.uni-heidelberg.de

Lab website

FP1 Project 14 FP2 Project 14

Team

Mehsoon Gilani
Benjamin Richter, Clinical Scientist
Khwab Sanghvi, PhD student
David Vonhören, Postdoc

Publications

Type I interferon drives T cell responses to amyloid beta in the central nervous system

Michel, J. J., Sanghvi, K., Rosenbauer, J., Humbs, L., Dierssen, C. T., Grudzenski-Theis, S., Sachs, V., Jähne, K., Degenhardt, K., Frölich, L., Herms, J., Fatar, M., Platten, M., Bunse, L.

Nat Commun 17(1) (2026) doi: 10.1038/s41467-026-72262-6 pmid: 42026067

REVIEW:The immunology of brain tumors.

Bunse, L, Bunse, T., Kilian, M., Quintana, F.J., Platten, M..

Sci Immunol 10, 112 (2025) doi: 10.1126/sciimmunol.ads0449 pmid: 41042911

Cell type mapping of inflammatory muscle diseases highlights selective myofiber vulnerability in inclusion body myositis.

Wischnewski, S., Thäwel, T., Ikenaga, C., Kocharyan, A., Lerma-Martin, C., Zulji, A., Rausch, H. W., Brenner, D., Thomas, L., Kutza, M., Wick, B., Trobisch, T., Preusse, C., Haeussler, M., Leipe, J., Ludolph, A., Rosenbohm, A., Hoke, A., Platten, M., Weishaupt, J. H., Sommer, C. J., Stenzel, W., Lloyd, T. E., Schirmer, L.

Nat Aging 4, 7 (2024) doi: 10.1038/s43587-024-00645-9 pmid: 38834884

REVIEW Tumor-reactive T helper cells in the context of vaccination against glioma.

Zhao, B., Kilian, M., Bunse, T., Platten, M., Bunse, L.

Cancer Cell 41, 11 (2023) doi: 10.1016/j.ccell.2023.09.013 pmid: 37863064
Myeloid cell iron uptake pathways and paramagnetic rim formation in multiple sclerosis.

Hofmann, A., Krajnc, N., Dal-Bianco, A., Riedl, C. J., Zrzavy, T., Lerma-Martin, C., Kasprian, G., Weber, C. E., Pezzini, F., Leutmezer, F., Rommer, P., Bsteh, G., Platten, M., Gass, A., Berger, T., Eisele, P., Magliozzi, R., Schirmer, L., Hametner, S.

Acta Neuropathol 146, 5 (2023) doi: 10.1007/s00401-023-02627-4 pmid: 37715818
MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors.

Kilian, M., Sheinin, R., Tan, C. L., Friedrich, M., Krämer, C., Kaminitz, A., Sanghvi, K., Lindner, K., Chih, Y. C., Cichon, F., Richter, B., Jung, S., Jähne, K., Ratliff, M., Prins, R. M., Etminan, N., von Deimling, A., Wick, W., Madi, A., Bunse, L., Platten, M.

Cancer Cell 41, 2 (2023) doi: 10.1016/j.ccell.2022.12.007 pmid: 36638785