SPP 2395 – Publications

Publications

PinkyCaMP: an mScarlet-based calcium sensor with enhanced brightness, photostability and multiplexing capabilities

Fink, R., Imai, S., Gockel, N., Lauer, G., Renken, K., Wietek, J., Lamothe-Molina, P. J., Fuhrmann, F., Mittag, M., Ziebarth, T., Canziani, A., Kubitschke, M., Kistmacher, V., Kretschmer, A., Sebastian, E., Ottens, J., Schmitz, D., Terai, T., Gründemann, J., Hassan, S. I., Patriarchi, T., Reiner, A., Fuhrmann, M., Campbell, R. E., Masseck, O. A.

Nat Methods (2026) doi: 10.1038/s41592-026-03065-2 pmid: 42032066
Type I interferon drives T cell responses to amyloid beta in the central nervous system

Michel, J. J., Sanghvi, K., Rosenbauer, J., Humbs, L., Dierssen, C. T., Grudzenski-Theis, S., Sachs, V., Jähne, K., Degenhardt, K., Frölich, L., Herms, J., Fatar, M., Platten, M., Bunse, L.

Nat Commun 17(1) (2026) doi: 10.1038/s41467-026-72262-6 pmid: 42026067
Microglia-glioblastoma crosstalk mediates glioblastoma invasion at the far infiltration zone

Nebeling, F. C., Fuhrmann, F., Mittag, M., Musacchio, F., Antony, H., Gockel, N., Friker, L. L., Leonardelli, S., Filser, S., A, D., Stork, M., Bano, D., Pietsch, T., Giordano, F. A., Zhou, Q., Parrinello, S., Hölzel, M., Herrlinger, U., Salomoni, P., Fuhrmann, M.

Immunity (2026) doi: 10.1016/j.immuni.2026.03.010 pmid: 41923645
A scalable human-zebrafish xenotransplantation model reveals gastrosome-mediated processing of dying neurons by human microglia

Villani, A., Wittmann, J., Wyss, T., Mallona, I., Santisteban Ortiz, I., Tichy, N., Biermeier, C. M., Pena, M., Pal, A. A., Gilmour, D., Schafer, S. T., Peri, F.

Commun Biol (2026) doi: 10.1038/s42003-026-09948-6 pmid: 41957412
Schizophrenia-associated complement C4 impairs synaptic connectivity and decreases microglia-synapse interactions through CR3 signaling

Gockel, N., Nieves-Rivera, N., Druart, M., Jaako, K., Fuhrmann, F., Musacchio, F., Antony, H., Mittag, M., Crux-Daseking, S., Poll, S., Jansone, B., Fuhrmann, M., Le Magueresse, C.

Cell Rep (2026) doi: 10.1016/j.celrep.2026.117161 pmid: 41903141

Cerebral ischaemic stroke results in altered mucosal antibody responses and host-commensal microbiota interactions

Hurry, M., Posner, D.A., Wong, R., Grayston, A., Díaz-Marugan, L., Zhang, X., De Leon, B., Benakis, C., Waisman, A., McCulloch, L., Allan, S.M., Lawrence, C.B., Brough, D., Hepworth, M.R.

Brain Behav Immun 131 (2025) doi: 10.1016/j.bbi.2025.106184 pmid: 41265660
Neuron subtypes have distinct mitochondrial transport in axons and vulnerability to tau in vivo

Niedermeier, T., Feyen, P., Ochs, K., Misgeld, T., Herms, J., Paeger, L.

Natureportfolio under review (2025) doi: 10.21203/rs.3.rs-7628051/v1
REVIEW:The immunology of brain tumors.

Bunse, L, Bunse, T., Kilian, M., Quintana, F.J., Platten, M..

Sci Immunol 10, 112 (2025) doi: 10.1126/sciimmunol.ads0449 pmid: 41042911
Multicolor fate mapping of microglia reveals polyclonal proliferation, heterogeneity, and cell-cell interactions after ischemic stroke in mice.

Kikhia, M., Schilling, S., Herzog, M.-L., Livne, M., Semtner, M., Tay, T.L., Prinz, M., Kettenmann, H., Endres, M., Kronenberg, G., Göttert, R., Gertz, K.

Nat Commun 16 (2025) doi: 10.1038/s41467-025-63949-3 pmid: 40957877
Early Locus Coeruleus noradrenergic axon loss drives olfactory dysfunction in Alzheimer/’s disease

Meyer, C., Niedermeier, T., Feyen, P.L.C., Strübing, F.L., Rauchmann, B.-S., Karali, K., Gentz, J., Tillmann, Y.E., Landgraf, N.F., Rumpf, S.-L., Ochs, K., Wind-Mark, K., Biechele, G., Wagner, J., Guersel, S., Kurz, C.I., Schweiger, M., Prtvar, D., Shi, Y., Banati, R.B., Liu, G.-J., Middleton, R.J., Mitteregger-Kretzschmar, G., Perneczky, R., Koeglsperger, T., Neher, J.J., Tahirovic, S., Brendel, M., Herms, J., Paeger, L.

Nat Commun 16 (2025) doi: 10.1038/s41467-025-62500-8 pmid: 40781079
Three-photon in vivo imaging of neurons and glia in the medial prefrontal cortex with sub-cellular resolution

Fuhrmann, F., Nebeling, F. C., Musacchio, F., Fuhrmann, M.

Commun Biol (2025) doi: 10.1038/s42003-025-08079-8 pmid: 40410447

Myeloid cell-specific loss of NPC1 in mice recapitulates microgliosis and neurodegeneration in patients with Niemann-Pick type C disease.

Dinkel, L., Hummel, S., Zenatti, V., Malara, M., Tillmann, Y., Colombo, A., Monasor, L. S., Suh, J. H., Logan, T., Roth, S., Paeger, L., Hoffelner, P., Bludau, O., Schmidt, A., Muller, S. A., Schifferer, M., Nuscher, B., Njavro, J. R., Prestel, M., Bartos, L. M., Wind-Mark, K., Slemann, L., Hoermann, L., Kunte, S. T., Gnorich, J., Lindner, S., Simons, M., Herms, J., Paquet, D., Lichtenthaler, S. F., Bartenstein, P., Franzmeier, N., Liesz, A., Grosche, A., Bremova-Ertl, T., Catarino, C., Beblo, S., Bergner, C., Schneider, S. A., Strupp, M., Di Paolo, G., Brendel, M., Tahirovic, S.

Sci Transl Med 16, 776 (2024) doi: 10.1126/scitranslmed.adl4616 pmid: 39630885
Cell type mapping of inflammatory muscle diseases highlights selective myofiber vulnerability in inclusion body myositis.

Lerma-Martin, C., Badia, I. M. P., Ramirez Flores, R. O., Sekol, P., Schäfer, P. S. L., Riedl, C. J., Hofmann, A., Thäwel, T., Wünnemann, F., Ibarra-Arellano, M. A., Trobisch, T., Eisele, P., Schapiro, D., Haeussler, M., Hametner, S., Saez-Rodriguez, J., Schirmer, L.

Nat Neurosci 27 (2024) doi: 10.1038/s41593-024-01796-z pmid: 39501036
Decreased sialylation elicits complement-related microglia response and bipolar cell loss in the mouse retina.

Cuevas-Rios, G., Assale, T. A., Wissfeld, J., Bungartz, A., Hofmann, J., Langmann, T., Neumann, H.

Glia 72, 12 (2024) doi: 10.1002/glia.24613 pmid: 39228105
The potential therapeutic role of itaconate and mesaconate on the detrimental effects of LPS-induced neuroinflammation in the brain.

Ohm, M., Hosseini, S., Lonnemann, N., He, W., More, T., Goldmann, O., Medina, E., Hiller, K., Korte, M.

J Neuroinflammation 21, 1 (2024) doi: 10.1186/s12974-024-03188-3 pmid: 39164713
Myeloid cells coordinately induce glioma cell-intrinsic and cell-extrinsic pathways for chemoresistance via GP130 signaling.

Cheng, J., Li, M., Motta, E., Barci, D., Song, W., Zhou, D., Li, G., Zhu, S., Yang, A., Vaillant, B. D., Imhof, A., Forné, I., Spiegl-Kreinecker, S., Zhang, N., Katayama, H., Bhat, K. P. L., Flüh, C., Kälin, R. E., Glass, R.

Cell Rep Med 5, 8 (2024) doi: 10.1016/j.xcrm.2024.101658 pmid: 39053460
H7N7 viral infection elicits pronounced, sex-specific neuroinflammatory responses in vitro.

Gabele, L., Bochow, I., Rieke, N., Sieben, C., Michaelsen-Preusse, K., Hosseini, S., Korte, M.

Front Cell Neurosci 18 (2024) doi: 10.3389/fncel.2024.1444876 pmid: 39171200
REVIEW Changes in Neuroimmunological Synapses During Cerebral Ischemia.

Bitar, L., Puig, B., Oertner, T. G., Dénes, Á., Magnus, T.

Transl Stroke Res (2024) doi: 10.1007/s12975-024-01286-1 pmid: 39103660
REVIEW Iron scavenging and myeloid cell polarization.

Ludwig, N., Cucinelli, S., Hametner, S., Muckenthaler, M. U., Schirmer, L.

Trends Immunol 45, 8 (2024) doi: 10.1016/j.it.2024.06.006 pmid: 39054114
Aberrant hippocampal Ca(2+) microwaves following synapsin-dependent adeno-associated viral expression of Ca(2+) indicators.

Masala, N., Mittag, M., Giovannetti, E. A., O'Neil, D. A., Distler, F. J., Rupprecht, P., Helmchen, F., Yuste, R., Fuhrmann, M., Beck, H., Wenzel, M., Kelly, T.

Elife 13 (2024) doi: 10.7554/eLife.93804 pmid: 39042440
T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis.

Kedia, S., Ji, H., Feng, R., Androvic, P., Spieth, L., Liu, L., Franz, J., Zdiarstek, H., Anderson, K. P., Kaboglu, C., Liu, Q., Mattugini, N., Cherif, F., Prtvar, D., Cantuti-Castelvetri, L., Liesz, A., Schifferer, M., Stadelmann, C., Tahirovic, S., Gokce, O., Simons, M.

Nat Neurosci 27 (2024) doi: 10.1038/s41593-024-01682-8 pmid: 38937583
Cell type mapping of inflammatory muscle diseases highlights selective myofiber vulnerability in inclusion body myositis.

Wischnewski, S., Thäwel, T., Ikenaga, C., Kocharyan, A., Lerma-Martin, C., Zulji, A., Rausch, H. W., Brenner, D., Thomas, L., Kutza, M., Wick, B., Trobisch, T., Preusse, C., Haeussler, M., Leipe, J., Ludolph, A., Rosenbohm, A., Hoke, A., Platten, M., Weishaupt, J. H., Sommer, C. J., Stenzel, W., Lloyd, T. E., Schirmer, L.

Nat Aging 4, 7 (2024) doi: 10.1038/s43587-024-00645-9 pmid: 38834884
The effects of urolithin A on poly I:C-induced microglial activation.

Mingo, Y. B., Gabele, L., Lonnemann, N., Brône, B., Korte, M., Hosseini, S.

Front Cell Neurosci 18 (2024) doi: 10.3389/fncel.2024.1343562 pmid: 38577490
REVIEW Therapeutic potential to target sialylation and SIGLECs in neurodegenerative and psychiatric diseases.

Wißfeld, J., Abou Assale, T., Cuevas-Rios, G., Liao, H., Neumann, H.

Front Neurol 15 (2024) doi: 10.3389/fneur.2024.1330874 pmid: 38529039
Microglia maintain structural integrity during fetal brain morphogenesis.

Lawrence, A. R., Canzi, A., Bridlance, C., Olivié, N., Lansonneur, C., Catale, C., Pizzamiglio, L., Kloeckner, B., Silvin, A., Munro, D. A. D., Fortoul, A., Boido, D., Zehani, F., Cartonnet, H., Viguier, S., Oller, G., Squarzoni, P., Candat, A., Helft, J., Allet, C., Watrin, F., Manent, J. B., Paoletti, P., Thieffry, D., Cantini, L., Pridans, C., Priller, J., Gélot, A., Giacobini, P., Ciobanu, L., Ginhoux, F., Thion, M. S., Lokmane, L., Garel, S.

Cell 187, 4 (2024) doi: 10.1016/j.cell.2024.01.012 pmid: 38309258
Intellectual Disability and Behavioral Deficits Linked to CYFIP1 Missense Variants Disrupting Actin Polymerization.

Mariano, V., Kanellopoulos, A. K., Ricci, C., Di Marino, D., Borrie, S. C., Dupraz, S., Bradke, F., Achsel, T., Legius, E., Odent, S., Billuart, P., Bienvenu, T., Bagni, C.

Biol Psychiatry 95, 2 (2024) doi: 10.1016/j.biopsych.2023.08.027 pmid: 37704042

Multiomic spatial landscape of innate immune cells at human central nervous system borders.

Sankowski, R., Süß, P., Benkendorff, A., Böttcher, C., Fernandez-Zapata, C., Chhatbar, C., Cahueau, J., Monaco, G., Gasull, A. D., Khavaran, A., Grauvogel, J., Scheiwe, C., Shah, M. J., Heiland, D. H., Schnell, O., Markfeld-Erol, F., Kunze, M., Zeiser, R., Priller, J., Prinz, M.

Nat Med 30, 1 (2023) doi: 10.1038/s41591-023-02673-1 pmid: 38123840
REVIEW Tumor-reactive T helper cells in the context of vaccination against glioma.

Zhao, B., Kilian, M., Bunse, T., Platten, M., Bunse, L.

Cancer Cell 41, 11 (2023) doi: 10.1016/j.ccell.2023.09.013 pmid: 37863064
REVIEW Nature and immune mechanisms of mental illnesses.

Priller, J., Schäfer, S., Safaiyan, S.

Nervenarzt 94, 11 (2023) doi: 10.1007/s00115-023-01554-9 pmid: 37815590
Myeloid cell iron uptake pathways and paramagnetic rim formation in multiple sclerosis.

Hofmann, A., Krajnc, N., Dal-Bianco, A., Riedl, C. J., Zrzavy, T., Lerma-Martin, C., Kasprian, G., Weber, C. E., Pezzini, F., Leutmezer, F., Rommer, P., Bsteh, G., Platten, M., Gass, A., Berger, T., Eisele, P., Magliozzi, R., Schirmer, L., Hametner, S.

Acta Neuropathol 146, 5 (2023) doi: 10.1007/s00401-023-02627-4 pmid: 37715818
An in vivo neuroimmune organoid model to study human microglia phenotypes.

Schafer, S. T., Mansour, A. A., Schlachetzki, J. C. M., Pena, M., Ghassemzadeh, S., Mitchell, L., Mar, A., Quang, D., Stumpf, S., Ortiz, I. S., Lana, A. J., Baek, C., Zaghal, R., Glass, C. K., Nimmerjahn, A., Gage, F. H.

Cell 186, 10 (2023) doi: 10.1016/j.cell.2023.04.022 pmid: 37172564
REVIEW Transplantation Strategies to Enhance Maturity and Cellular Complexity in Brain Organoids.

Wang, M., Gage, F. H., Schafer, S. T.

Biol Psychiatry 93, 7 (2023) doi: 10.1016/j.biopsych.2023.01.004 pmid: 36739209
Influenza vaccine is able to prevent neuroinflammation triggered by H7N7 IAV infection.

Demuth, L., Ohm, M., Michaelsen-Preusse, K., Schulze, K., Riese, P., Guzmán, C. A., Korte, M., Hosseini, S.

Front Pharmacol 14 (2023) doi: 10.3389/fphar.2023.1142639 pmid: 37063291
MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors.

Kilian, M., Sheinin, R., Tan, C. L., Friedrich, M., Krämer, C., Kaminitz, A., Sanghvi, K., Lindner, K., Chih, Y. C., Cichon, F., Richter, B., Jung, S., Jähne, K., Ratliff, M., Prins, R. M., Etminan, N., von Deimling, A., Wick, W., Madi, A., Bunse, L., Platten, M.

Cancer Cell 41, 2 (2023) doi: 10.1016/j.ccell.2022.12.007 pmid: 36638785
Microglial motility is modulated by neuronal activity and correlates with dendritic spine plasticity in the hippocampus of awake mice.

Nebeling, F. C., Poll, S., Justus, L. C., Steffen, J., Keppler, K., Mittag, M., Fuhrmann, M.

Elife 12 (2023) doi: 10.7554/eLife.83176 pmid: 36749020
Rehabilitation enhances epothilone-induced locomotor recovery after spinal cord injury.

Griffin, J. M., Hingorani Jai Prakash, S., Bockemühl, T., Benner, J. M., Schaffran, B., Moreno-Manzano, V., Büschges, A., Bradke, F.

Brain Commun 5, 1 (2023) doi: 10.1093/braincomms/fcad005 pmid: 36744011
REVIEW How viral infections cause neuronal dysfunction\:\ a focus on the role of microglia and astrocytes.

Hosseini, S., Korte, M.

Biochem Soc Trans 51, 1 (2023) doi: 10.1042/bst20220771 pmid: 36606670

Endothelial PlexinD1 signaling instructs spinal cord vascularization and motor neuron development.

Vieira, J. R., Shah, B., Dupraz, S., Paredes, I., Himmels, P., Schermann, G., Adler, H., Motta, A., Gärtner, L., Navarro-Aragall, A., Ioannou, E., Dyukova, E., Bonnavion, R., Fischer, A., Bonanomi, D., Bradke, F., Ruhrberg, C., Ruiz de Almodóvar, C.

Neuron 110, 24 (2022) doi: 10.1016/j.neuron.2022.12.005 pmid: 36549270
REVIEW Super-Resolution Microscopy Opens New Doors to Life at the Nanoscale.

Fuhrmann, M., Gockel, N., Arizono, M., Dembitskaya, Y., Nägerl, U. V., Pennacchietti, F., Damenti, M., Testa, I., Willig, K. I.

J Neurosci 42, 45 (2022) doi: 10.1523/jneurosci.1125-22.2022 pmid: 36351828
Lithium inhibits tryptophan catabolism via the inflammation-induced kynurenine pathway in human microglia.

Göttert, R., Fidzinski, P., Kraus, L., Schneider, U. C., Holtkamp, M., Endres, M., Gertz, K., Kronenberg, G.

Glia 70, 3 (2022) doi: 10.1002/glia.24123 pmid: 34862988

PinkyCaMP: an mScarlet-based calcium sensor with enhanced brightness, photostability and multiplexing capabilities

Fink, R., Imai, S., Gockel, N., Lauer, G., Renken, K., Wietek, J., Lamothe-Molina, P. J., Fuhrmann, F., Mittag, M., Ziebarth, T., Canziani, A., Kubitschke, M., Kistmacher, V., Kretschmer, A., Sebastian, E., Ottens, J., Schmitz, D., Terai, T., Gründemann, J., Hassan, S. I., Patriarchi, T., Reiner, A., Fuhrmann, M., Campbell, R. E., Masseck, O. A.

Nat Methods (2026) doi: 10.1038/s41592-026-03065-2 pmid: 42032066
Type I interferon drives T cell responses to amyloid beta in the central nervous system

Michel, J. J., Sanghvi, K., Rosenbauer, J., Humbs, L., Dierssen, C. T., Grudzenski-Theis, S., Sachs, V., Jähne, K., Degenhardt, K., Frölich, L., Herms, J., Fatar, M., Platten, M., Bunse, L.

Nat Commun 17(1) (2026) doi: 10.1038/s41467-026-72262-6 pmid: 42026067
Microglia-glioblastoma crosstalk mediates glioblastoma invasion at the far infiltration zone

Nebeling, F. C., Fuhrmann, F., Mittag, M., Musacchio, F., Antony, H., Gockel, N., Friker, L. L., Leonardelli, S., Filser, S., A, D., Stork, M., Bano, D., Pietsch, T., Giordano, F. A., Zhou, Q., Parrinello, S., Hölzel, M., Herrlinger, U., Salomoni, P., Fuhrmann, M.

Immunity (2026) doi: 10.1016/j.immuni.2026.03.010 pmid: 41923645
A scalable human-zebrafish xenotransplantation model reveals gastrosome-mediated processing of dying neurons by human microglia

Villani, A., Wittmann, J., Wyss, T., Mallona, I., Santisteban Ortiz, I., Tichy, N., Biermeier, C. M., Pena, M., Pal, A. A., Gilmour, D., Schafer, S. T., Peri, F.

Commun Biol (2026) doi: 10.1038/s42003-026-09948-6 pmid: 41957412
Schizophrenia-associated complement C4 impairs synaptic connectivity and decreases microglia-synapse interactions through CR3 signaling

Gockel, N., Nieves-Rivera, N., Druart, M., Jaako, K., Fuhrmann, F., Musacchio, F., Antony, H., Mittag, M., Crux-Daseking, S., Poll, S., Jansone, B., Fuhrmann, M., Le Magueresse, C.

Cell Rep (2026) doi: 10.1016/j.celrep.2026.117161 pmid: 41903141