Welcome to SPP2395

SPP2395 is a collaboratively supported priority programme on microglia research. With more than 30 principal investigators in two funding periods, we are driving 36 innovative projects across more than 20 research institutes in Germany, Israel, the United Kingdom, Switzerland and Finland. Together, we advance rigorous, transparent science to deepen our understanding of microglia in health and disease.

Our Mission

Microglia are the resident macrophages of the CNS, coordinating homeostatic regulation and mounting first-line immune responses. After two decades revealing their heterogeneity, the field is moving beyond simple “homeostatic” versus “disease-associated” labels toward context-aware biology in intact tissue. SPP2395 prioritizes in vivo investigation and the translation of preclinical insights using human post-mortem tissue, humanized mouse models, iPSC-derived human microglia, and patient data.

News

Upcoming Events

SPP2395 Online Meeting 2026#1 SPP2395 Annual Meeting 2026: "Turku, Finland"

Recent Publications

  • AuthorAuthor
    Cerebral ischaemic stroke results in altered mucosal antibody responses and host-commensal microbiota interactions
    Hurry, M., Posner, D.A., Wong, R., Grayston, A., Díaz-Marugan, L., Zhang, X., De Leon, B., Benakis, C., Waisman, A., McCulloch, L., Allan, S.M., Lawrence, C.B., Brough, D., Hepworth, M.R.
    Brain Behav Immun 131 (2025) doi: 10.1016/j.bbi.2025.106184 pmid: 41265660

Participating Institutions

Berlin Institute of Health Center for Molecular Neurobiology Hamburg Charité Berlin Christian-Albrechts-Universität zu Kiel DZNE Bonn DZNE München Experimental Research in Stroke and Inflammation Helmholtz-Zentrum für Infektionsforschung Imperial College London Institute for Stroke and Dementia Research LMU Klinikum München LMU München Mannheim Center for Translational Neuroscience Mannheim Institute for Innate Immunoscience Max Delbrück Center Berlin Medizinische Fakultät Heidelberg Medizinische Universität Wien TU Braunschweig TU München Uniklinik Heidelberg Universität zu Köln Universitätsklinikum Bonn Universitätsklinikum Freiburg Universitätsklinikum Hamburg-Eppendorf Universitätsklinikum Jena Universitätsklinikum Leipzig Universitätsklinikum Schleswig Holstein Universitätsmedizin Göttingen Universitätsmedizin Mainz Universitätsmedizin Mannheim Université de Genève University of Turku Weizmann Institute of Science