SPP 2395 – Projects

Collaboratively supported by more than 30 principal investigators, this priority project has pioneered 18 innovative projects in different funding periods (2022-2025 and 2025-2028) that span more than 20 diverse research institutes across Germany, Israel, the UK, Switzerland and Finland.

Aberrant microglia function as drivers of neuroaxonal degeneration in diseases of the white matter

Caroline Bergner, Stefan Nessler, Christine Stadelmann-Nessler

Aberrant microglia function as drivers of neuroaxonal degeneration in diseases of the white matter

Caroline Bergner, Stefan Nessler, Christine Stadelmann-Nessler

Universitätsklinikum Leipzig

Universitätsmedizin Göttingen

The continuum of microglial subpopulations to functional changes in multiple sclerosis

Chotima Böttcher, Zoltan Takats

The continuum of microglial subpopulations to functional changes in multiple sclerosis

Chotima Böttcher, Zoltan Takats

Imperial College London

The cytoskeleton as a signaling node that contributes to microglia activation and diversity

Frank Bradke, Annett Halle

The cytoskeleton as a signaling node that contributes to microglia activation and diversity

Frank Bradke, Annett Halle

The role of microglial cytoskeleton proteins ADF/Cfl1 in learning and memory

Sophie Crux-Daseking, Martin Fuhrmann

The role of microglial cytoskeleton proteins ADF/Cfl1 in learning and memory

Sophie Crux-Daseking, Martin Fuhrmann

Multidimensional analysis and therapeutic targeting of microglia fostering brain tumor relapse

Charlotte Flüh, Rainer Glass

Multidimensional analysis and therapeutic targeting of microglia fostering brain tumor relapse

Charlotte Flüh, Rainer Glass

Universitätsklinikum Schleswig Holstein

LMU Klinikum München

A humanized mouse model to analyse the age-dependent impact of gut microbiota on microglial diversity in the brain

Christoph Kaleta, Christiane Frahm, Christian Schmeer

A humanized mouse model to analyse the age-dependent impact of gut microbiota on microglial diversity in the brain

Christoph Kaleta, Christiane Frahm, Christian Schmeer

Universitätsklinikum Jena

Christian-Albrechts-Universität zu Kiel

Myeloid Cell Diversity and Ischemic Stroke

Myeloid Cell Diversity and Ischemic Stroke

Elucidating the role of activated microglia in sculpting neuronal circuits after respiratory viral infections

Shirin Hosseini, Martin Korte

Elucidating the role of activated microglia in sculpting neuronal circuits after respiratory viral infections

Shirin Hosseini, Martin Korte

TU Braunschweig

Helmholtz-Zentrum für Infektionsforschung

Microglial IL-10 expression and the impact of CNS-wide microglia responses on higher brain function

Microglial IL-10 expression and the impact of CNS-wide microglia responses on higher brain function

Weizmann Institute of Science

Desialyation as trigger of microglia responses in the aging and degenerating retina

Harald Neumann, Thomas Langmann

Desialyation as trigger of microglia responses in the aging and degenerating retina

Harald Neumann, Thomas Langmann

Universität zu Köln

Universitätsklinikum Bonn

T cells as modulators of microglial reactivity in Alzheimer’s disease

Sabina Tahirovic, Arthur Liesz

T cells as modulators of microglial reactivity in Alzheimer’s disease

Sabina Tahirovic, Arthur Liesz

LMU Klinikum München

Microglia-neuron interaction during recovery after cerebral ischemia

Tim Magnus, Thomas Oertner

Microglia-neuron interaction during recovery after cerebral ischemia

Tim Magnus, Thomas Oertner

Universitätsklinikum Hamburg-Eppendorf

Center for Molecular Neurobiology Hamburg

Experimental Research in Stroke and Inflammation

Microglial lipid metabolism during physiological and pathological conditions

Alexander Mildner

Microglial lipid metabolism during physiological and pathological conditions

Alexander Mildner

University of Turku

Microglial immunosurveillance of oncogenic isocitrate dehydrogenase (CONVINCE-IDH)

Lukas Bunse, Michael Platten

Microglial immunosurveillance of oncogenic isocitrate dehydrogenase (CONVINCE-IDH)

Lukas Bunse, Michael Platten

Universitätsmedizin Mannheim

Medizinische Fakultät Heidelberg

Mannheim Center for Translational Neuroscience

A novel in vivo human-mouse chimeric brain model to study human microglia specification and contributions to neuropsychiatric disease

Josef Priller, Simon Schäfer

A novel in vivo human-mouse chimeric brain model to study human microglia specification and contributions to neuropsychiatric disease

Josef Priller, Simon Schäfer

MacTrac – Tracking spatio-temporal trajectories of macrophage subtypes in inflammatory demyelination

Julio Saez-Rodriguez, Lucas Schirmer, Simon Hametner

MacTrac – Tracking spatio-temporal trajectories of macrophage subtypes in inflammatory demyelination

Julio Saez-Rodriguez, Lucas Schirmer, Simon Hametner

Universitätsmedizin Mannheim

Mannheim Institute for Innate Immunoscience

Mannheim Center for Translational Neuroscience

Medizinische Fakultät Heidelberg

Uniklinik Heidelberg

Medizinische Universität Wien

Epigenomic states of microglia driving central nervous system repair in humans

Epigenomic states of microglia driving central nervous system repair in humans

Max Delbrück Center Berlin

Berlin Institute of Health

The role of CYLD and A20 in microglia in aging and autoimmunity

The role of CYLD and A20 in microglia in aging and autoimmunity

Universitätsmedizin Mainz

Chronic exposure to environmental pollutants and microglial molecular reprogramming in ischemic stroke

Corinne Benakis

Chronic exposure to environmental pollutants and microglial molecular reprogramming in ischemic stroke

Corinne Benakis

LMU Klinikum München

Institute for Stroke and Dementia Research

Microglia instruct the toxic microenvironment in transplantable leukodystrophies

Caroline Bergner, Stefan Nessler, Christine Stadelmann-Nessler

Microglia instruct the toxic microenvironment in transplantable leukodystrophies

Caroline Bergner, Stefan Nessler, Christine Stadelmann-Nessler

Universitätsklinikum Leipzig

Universitätsmedizin Göttingen

Actin cytoskeleton disturbance as a driver of cellular dysfunction and cell state diversity in microglia

Frank Bradke, Annett Halle

Actin cytoskeleton disturbance as a driver of cellular dysfunction and cell state diversity in microglia

Frank Bradke, Annett Halle

The role of microtubule cytoskeleton modulation in microglia and its effect on cognition

Sophie Crux-Daseking, Martin Fuhrmann

The role of microtubule cytoskeleton modulation in microglia and its effect on cognition

Sophie Crux-Daseking, Martin Fuhrmann

Microglial dynamics in retinal diseases: Müller cells and T cells as local and peripheral interacting partners

Cornelia Deeg, Antje Grosche

Microglial dynamics in retinal diseases: Müller cells and T cells as local and peripheral interacting partners

Cornelia Deeg, Antje Grosche

Spatio-temporal profiling of microglial heterogeneity and dynamics in glioblastoma

Felix Nebeling, Martin Fuhrmann

Spatio-temporal profiling of microglial heterogeneity and dynamics in glioblastoma

Felix Nebeling, Martin Fuhrmann

Microglial IL-10 and Csf1r dependence - harnessing mouse models to decipher microglia biology

Microglial IL-10 and Csf1r dependence - harnessing mouse models to decipher microglia biology

Weizmann Institute of Science

The role of translation in shaping microglial activation states during neuroinflammation

Michael Kiebler, Jovica Ninkovic

The role of translation in shaping microglial activation states during neuroinflammation

Michael Kiebler, Jovica Ninkovic

LMU Klinikum München

Microglial diversity in the remodeling of GABAergic synapses in corticolimbic circuits and anxiety-related behaviors

Dilja Krüger-Burg

Microglial diversity in the remodeling of GABAergic synapses in corticolimbic circuits and anxiety-related behaviors

Dilja Krüger-Burg

Universitätsmedizin Mainz

T cells as modulators of microglia-mediated neurodegeneration in Niemann Pick type C (NPC) disease

Sabina Tahirovic, Arthur Liesz

T cells as modulators of microglia-mediated neurodegeneration in Niemann Pick type C (NPC) disease

Sabina Tahirovic, Arthur Liesz

LMU Klinikum München

Genetic and non-genetic determinants of brain cancer-associated clonal myeloid cell dynamics and plasticity

Ilon Liu, Leif S. Ludwig

Genetic and non-genetic determinants of brain cancer-associated clonal myeloid cell dynamics and plasticity

Ilon Liu, Leif S. Ludwig

Max Delbrück Center Berlin

Berlin Institute of Health

Influence of cytokines on microglial metabolism during Alzheimer’s disease

Alexander Mildner

Influence of cytokines on microglial metabolism during Alzheimer’s disease

Alexander Mildner

University of Turku

Spatiotemporally resolved microglial diversity and reciprocal interaction with the noradrenergic system in Alzheimer’s disease

Lars Paeger, Felix Strübing

Spatiotemporally resolved microglial diversity and reciprocal interaction with the noradrenergic system in Alzheimer’s disease

Lars Paeger, Felix Strübing

LMU Klinikum München

Trained Spp1+ microglial immunity in glioma – (TRAINSPOTTING)

Michael Platten

Trained Spp1+ microglial immunity in glioma – (TRAINSPOTTING)

Michael Platten

Universitätsmedizin Mannheim

Medizinische Fakultät Heidelberg

Mannheim Center for Translational Neuroscience

Charting CNS-endogenous innate immune responses across cells and species

Charting CNS-endogenous innate immune responses across cells and species

Universitätsklinikum Freiburg

Elucidating sex-specific and disease-associated human microglia phenotypes and their contribution to Rett Syndrome

Josef Priller, Simon Schäfer

Elucidating sex-specific and disease-associated human microglia phenotypes and their contribution to Rett Syndrome

Josef Priller, Simon Schäfer

CD8+ tissue-resident T-cell regulation of microglia function

Mikael Simons, Doron Merkler

CD8+ tissue-resident T-cell regulation of microglia function

Mikael Simons, Doron Merkler

Université de Genève

The deubiquitinating enzyme A20 as gate keepers of central nervous system homeostasis

The deubiquitinating enzyme A20 as gate keepers of central nervous system homeostasis

Universitätsmedizin Mainz