SPP 2395 – Publications

Publications

Myeloid cell-specific loss of NPC1 in mice recapitulates microgliosis and neurodegeneration in patients with Niemann-Pick type C disease.

Dinkel, L., Hummel, S., Zenatti, V., Malara, M., Tillmann, Y., Colombo, A., Monasor, L. S., Suh, J. H., Logan, T., Roth, S., Paeger, L., Hoffelner, P., Bludau, O., Schmidt, A., Muller, S. A., Schifferer, M., Nuscher, B., Njavro, J. R., Prestel, M., Bartos, L. M., Wind-Mark, K., Slemann, L., Hoermann, L., Kunte, S. T., Gnorich, J., Lindner, S., Simons, M., Herms, J., Paquet, D., Lichtenthaler, S. F., Bartenstein, P., Franzmeier, N., Liesz, A., Grosche, A., Bremova-Ertl, T., Catarino, C., Beblo, S., Bergner, C., Schneider, S. A., Strupp, M., Di Paolo, G., Brendel, M., Tahirovic, S.

Sci Transl Med 16,776 (2024) doi: 10.1126/scitranslmed.adl4616 pmid: 39630885
Cell type mapping of inflammatory muscle diseases highlights selective myofiber vulnerability in inclusion body myositis.

Lerma-Martin, C., Badia, I. M. P., Ramirez Flores, R. O., Sekol, P., Schäfer, P. S. L., Riedl, C. J., Hofmann, A., Thäwel, T., Wünnemann, F., Ibarra-Arellano, M. A., Trobisch, T., Eisele, P., Schapiro, D., Haeussler, M., Hametner, S., Saez-Rodriguez, J., Schirmer, L.

Nat Neurosci (2024) doi: 10.1038/s41593-024-01796-z pmid: 39501036
Decreased sialylation elicits complement-related microglia response and bipolar cell loss in the mouse retina.

Cuevas-Rios, G., Assale, T. A., Wissfeld, J., Bungartz, A., Hofmann, J., Langmann, T., Neumann, H.

Glia 72,12 (2024) doi: 10.1002/glia.24613 pmid: 39228105
T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis.

Kedia, S., Ji, H., Feng, R., Androvic, P., Spieth, L., Liu, L., Franz, J., Zdiarstek, H., Anderson, K. P., Kaboglu, C., Liu, Q., Mattugini, N., Cherif, F., Prtvar, D., Cantuti-Castelvetri, L., Liesz, A., Schifferer, M., Stadelmann, C., Tahirovic, S., Gokce, O., Simons, M.

Nat Neurosci 27 (2024) doi: 10.1038/s41593-024-01682-8 pmid: 38937583
Aberrant hippocampal Ca(2+) microwaves following synapsin-dependent adeno-associated viral expression of Ca(2+) indicators.

Masala, N., Mittag, M., Giovannetti, E. A., O'Neil, D. A., Distler, F. J., Rupprecht, P., Helmchen, F., Yuste, R., Fuhrmann, M., Beck, H., Wenzel, M., Kelly, T.

Elife 13 (2024) doi: 10.7554/eLife.93804 pmid: 39042440
Cell type mapping of inflammatory muscle diseases highlights selective myofiber vulnerability in inclusion body myositis.

Wischnewski, S., Thäwel, T., Ikenaga, C., Kocharyan, A., Lerma-Martin, C., Zulji, A., Rausch, H. W., Brenner, D., Thomas, L., Kutza, M., Wick, B., Trobisch, T., Preusse, C., Haeussler, M., Leipe, J., Ludolph, A., Rosenbohm, A., Hoke, A., Platten, M., Weishaupt, J. H., Sommer, C. J., Stenzel, W., Lloyd, T. E., Schirmer, L.

Nat Aging 4,7 (2024) doi: 10.1038/s43587-024-00645-9 pmid: 38834884
Intellectual Disability and Behavioral Deficits Linked to CYFIP1 Missense Variants Disrupting Actin Polymerization.

Mariano, V., Kanellopoulos, A. K., Ricci, C., Di Marino, D., Borrie, S. C., Dupraz, S., Bradke, F., Achsel, T., Legius, E., Odent, S., Billuart, P., Bienvenu, T., Bagni, C.

Biol Psychiatry 95,2 (2024) doi: 10.1016/j.biopsych.2023.08.027 pmid: 37704042
Multiomic spatial landscape of innate immune cells at human central nervous system borders.

Sankowski, R., Süß, P., Benkendorff, A., Böttcher, C., Fernandez-Zapata, C., Chhatbar, C., Cahueau, J., Monaco, G., Gasull, A. D., Khavaran, A., Grauvogel, J., Scheiwe, C., Shah, M. J., Heiland, D. H., Schnell, O., Markfeld-Erol, F., Kunze, M., Zeiser, R., Priller, J., Prinz, M.

Nat Med 30,1 (2024) doi: 10.1038/s41591-023-02673-1 pmid: 38123840
Microglia maintain structural integrity during fetal brain morphogenesis.

Lawrence, A. R., Canzi, A., Bridlance, C., Olivié, N., Lansonneur, C., Catale, C., Pizzamiglio, L., Kloeckner, B., Silvin, A., Munro, D. A. D., Fortoul, A., Boido, D., Zehani, F., Cartonnet, H., Viguier, S., Oller, G., Squarzoni, P., Candat, A., Helft, J., Allet, C., Watrin, F., Manent, J. B., Paoletti, P., Thieffry, D., Cantini, L., Pridans, C., Priller, J., Gélot, A., Giacobini, P., Ciobanu, L., Ginhoux, F., Thion, M. S., Lokmane, L., Garel, S.

Cell 187,4 (2024) doi: 10.1016/j.cell.2024.01.012 pmid: 38309258
The potential therapeutic role of itaconate and mesaconate on the detrimental effects of LPS-induced neuroinflammation in the brain.

Ohm, M., Hosseini, S., Lonnemann, N., He, W., More, T., Goldmann, O., Medina, E., Hiller, K., Korte, M.

J Neuroinflammation 21,1 (2024) doi: 10.1186/s12974-024-03188-3 pmid: 39164713
Myeloid cells coordinately induce glioma cell-intrinsic and cell-extrinsic pathways for chemoresistance via GP130 signaling.

Cheng, J., Li, M., Motta, E., Barci, D., Song, W., Zhou, D., Li, G., Zhu, S., Yang, A., Vaillant, B. D., Imhof, A., Forné, I., Spiegl-Kreinecker, S., Zhang, N., Katayama, H., Bhat, K. P. L., Flüh, C., Kälin, R. E., Glass, R.

Cell Rep Med 5,8 (2024) doi: 10.1016/j.xcrm.2024.101658 pmid: 39053460
REVIEW Changes in Neuroimmunological Synapses During Cerebral Ischemia.

Bitar, L., Puig, B., Oertner, T. G., Dénes, Á., Magnus, T.

Transl Stroke Res (2024) doi: 10.1007/s12975-024-01286-1 pmid: 39103660
REVIEW Iron scavenging and myeloid cell polarization.

Ludwig, N., Cucinelli, S., Hametner, S., Muckenthaler, M. U., Schirmer, L.

Trends Immunol 45,8 (2024) doi: 10.1016/j.it.2024.06.006 pmid: 39054114
REVIEW Therapeutic potential to target sialylation and SIGLECs in neurodegenerative and psychiatric diseases.

Wißfeld, J., Abou Assale, T., Cuevas-Rios, G., Liao, H., Neumann, H.

Front Neurol 15 (2024) doi: 10.3389/fneur.2024.1330874 pmid: 38529039
The effects of urolithin A on poly I:C-induced microglial activation.

Mingo, Y. B., Gabele, L., Lonnemann, N., Brône, B., Korte, M., Hosseini, S.

Front Cell Neurosci 18 (2024) doi: 10.3389/fncel.2024.1343562 pmid: 38577490
H7N7 viral infection elicits pronounced, sex-specific neuroinflammatory responses in vitro.

Gabele, L., Bochow, I., Rieke, N., Sieben, C., Michaelsen-Preusse, K., Hosseini, S., Korte, M.

Front Cell Neurosci 18 (2024) doi: 10.3389/fncel.2024.1444876 pmid: 39171200

Myeloid cell iron uptake pathways and paramagnetic rim formation in multiple sclerosis.

Hofmann, A., Krajnc, N., Dal-Bianco, A., Riedl, C. J., Zrzavy, T., Lerma-Martin, C., Kasprian, G., Weber, C. E., Pezzini, F., Leutmezer, F., Rommer, P., Bsteh, G., Platten, M., Gass, A., Berger, T., Eisele, P., Magliozzi, R., Schirmer, L., Hametner, S.

Acta Neuropathol 146,5 (2023) doi: 10.1007/s00401-023-02627-4 pmid: 37715818
REVIEW Tumor-reactive T helper cells in the context of vaccination against glioma.

Zhao, B., Kilian, M., Bunse, T., Platten, M., Bunse, L.

Cancer Cell 41,11 (2023) doi: 10.1016/j.ccell.2023.09.013 pmid: 37863064
REVIEW ature and immune mechanisms of mental illnesses.

Priller, J., Schäfer, S., Safaiyan, S.

Nervenarzt 94,11 (2023) doi: 10.1007/s00115-023-01554-9 pmid: 37815590
An in vivo neuroimmune organoid model to study human microglia phenotypes.

Schafer, S. T., Mansour, A. A., Schlachetzki, J. C. M., Pena, M., Ghassemzadeh, S., Mitchell, L., Mar, A., Quang, D., Stumpf, S., Ortiz, I. S., Lana, A. J., Baek, C., Zaghal, R., Glass, C. K., Nimmerjahn, A., Gage, F. H.

Cell 186,10 (2023) doi: 10.1016/j.cell.2023.04.022 pmid: 37172564
REVIEW How viral infections cause neuronal dysfunction\:\ a focus on the role of microglia and astrocytes.

Hosseini, S., Korte, M.

Biochem Soc Trans 51,1 (2023) doi: 10.1042/bst20220771 pmid: 36606670
MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors.

Kilian, M., Sheinin, R., Tan, C. L., Friedrich, M., Krämer, C., Kaminitz, A., Sanghvi, K., Lindner, K., Chih, Y. C., Cichon, F., Richter, B., Jung, S., Jähne, K., Ratliff, M., Prins, R. M., Etminan, N., von Deimling, A., Wick, W., Madi, A., Bunse, L., Platten, M.

Cancer Cell 41,2 (2023) doi: 10.1016/j.ccell.2022.12.007 pmid: 36638785
Microglial motility is modulated by neuronal activity and correlates with dendritic spine plasticity in the hippocampus of awake mice.

Nebeling, F. C., Poll, S., Justus, L. C., Steffen, J., Keppler, K., Mittag, M., Fuhrmann, M.

Elife 12 (2023) doi: 10.7554/eLife.83176 pmid: 36749020
REVIEW Transplantation Strategies to Enhance Maturity and Cellular Complexity in Brain Organoids.

Wang, M., Gage, F. H., Schafer, S. T.

Biol Psychiatry 93,7 (2023) doi: 10.1016/j.biopsych.2023.01.004 pmid: 36739209
Rehabilitation enhances epothilone-induced locomotor recovery after spinal cord injury.

Griffin, J. M., Hingorani Jai Prakash, S., Bockemühl, T., Benner, J. M., Schaffran, B., Moreno-Manzano, V., Büschges, A., Bradke, F.

Brain Commun 5,1 (2023) doi: 10.1093/braincomms/fcad005 pmid: 36744011
Influenza vaccine is able to prevent neuroinflammation triggered by H7N7 IAV infection.

Demuth, L., Ohm, M., Michaelsen-Preusse, K., Schulze, K., Riese, P., Guzmán, C. A., Korte, M., Hosseini, S.

Front Pharmacol 14 (2023) doi: 10.3389/fphar.2023.1142639 pmid: 37063291

REVIEW Super-Resolution Microscopy Opens New Doors to Life at the Nanoscale.

Fuhrmann, M., Gockel, N., Arizono, M., Dembitskaya, Y., Nägerl, U. V., Pennacchietti, F., Damenti, M., Testa, I., Willig, K. I.

J Neurosci 42,45 (2022) doi: 10.1523/jneurosci.1125-22.2022 pmid: 36351828
Lithium inhibits tryptophan catabolism via the inflammation-induced kynurenine pathway in human microglia.

Göttert, R., Fidzinski, P., Kraus, L., Schneider, U. C., Holtkamp, M., Endres, M., Gertz, K., Kronenberg, G.

Glia 70,3 (2022) doi: 10.1002/glia.24123 pmid: 34862988
Endothelial PlexinD1 signaling instructs spinal cord vascularization and motor neuron development.

Vieira, J. R., Shah, B., Dupraz, S., Paredes, I., Himmels, P., Schermann, G., Adler, H., Motta, A., Gärtner, L., Navarro-Aragall, A., Ioannou, E., Dyukova, E., Bonnavion, R., Fischer, A., Bonanomi, D., Bradke, F., Ruhrberg, C., Ruiz de Almodóvar, C.

Neuron 110,24 (2022) doi: 10.1016/j.neuron.2022.12.005 pmid: 36549270